{"Id":"225d1724-cba1-474b-b200-b02a712eed8d","CanonicalId":"doi:10.17504/protocols.io.bu9nnz5e","Url":"https://doi.org/10.17504/protocols.io.bu9nnz5e","Name":"Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells","Description":"This is a standard protocol for the engraftment of human HSC into 21-day-old NOD-scid IL2rγ (NSG) mice using an intravenous injection approach. Also described is the multiparameter flow cytometry used to monitor human immune system development and the kinetics of development. ","ResourceType":"Protocol","ParentResourceType":null,"DefiningManuscriptId":"PMID27150084","Publications":[],"Contributors":[{"Role":{"CanonicalId":"hirn-cv-ResourceRole-producer","Url":null,"Name":"Producer","OntologyId":null},"HirnUserId":"michael_brehm@hirnetwork.org","FirstName":"Michael","LastName":"Brehm","EmailAddress":"michael.brehm@umassmed.edu","Organization":"University of Massachusetts Medical School","Consortia":["CMAI"]},{"Role":{"CanonicalId":"hirn-cv-ResourceRole-producer","Url":null,"Name":"Producer","OntologyId":null},"HirnUserId":"dale_greiner@hirnetwork.org","FirstName":"Dale","LastName":"Greiner","EmailAddress":"Dale.greiner@umassmed.edu","Organization":"University of Massachusetts Medical School","Consortia":["CMAI"]},{"Role":{"CanonicalId":"hirn-cv-ResourceRole-producer","Url":null,"Name":"Producer","OntologyId":null},"HirnUserId":"leonard_shultz@hirnetwork.org","FirstName":"Leonard","LastName":"Shultz","EmailAddress":"lenny.shultz@jax.org","Organization":"The Jackson Laboratory","Consortia":["CMAI"]}],"Vendor":{"id":null,"Name":"","Url":null},"VendorResourceName":null,"VendorResourceUrl":"","VendorCatNumber":"","VendorLotNumber":"","DateCreated":"2021-04-29T18:58:04.2457264+00:00","DateModified":"2022-07-01T03:36:55.5833975+00:00","VersionId":"1","ModelVersion":"4.0","ProtocolData":{"ProtocolType":{"CanonicalId":null,"Url":null,"Name":null,"OntologyId":null},"DocumentId":null,"ProtocolSpecies":[],"DocumentTopic":[]}}