{"Id":"2d843144-0abf-4508-a8d5-62442fee5736","CanonicalId":"GSE148073","Url":"https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE148073","Name":"Single-cell transcriptomic resolution of human pancreatic islets reveals cellular states and intercellular interactions associated with type 1 diabetes","Description":"Our transcriptomic phenotyping of pancreatic cell types provides novel insights into pancreas biology, as well as the initial pathogenic events in T1D. We employed single-cell transcriptomics (10x Genomics Platform) on 35,134 cells from pancreatic islets of organ donors representing three disease states: those with T1D, those with autoantibodies (AAbs) towards pancreatic islet proteins but without a medical history of T1D (referred to as ‘AAB+’ donors), and donors without relevant AAbs or a history of diabetes (referred to as ‘Control’ donors)\n \t","ResourceType":"Dataset","ParentResourceType":null,"DefiningManuscriptId":"PMID35228745","Publications":[],"Contributors":[{"Role":{"CanonicalId":"hirn-cv-ResourceRole-contact","Url":null,"Name":"Contact","OntologyId":null},"HirnUserId":"klaus_kaestner@hirnetwork.org","FirstName":"Klaus","LastName":"Kaestner","EmailAddress":"kaestner@mail.med.upenn.edu","Organization":"University of Pennsylvania","Consortia":["CTAR","HPAC","OPP","CBDS"]},{"Role":{"CanonicalId":"hirn-cv-ResourceRole-contact","Url":null,"Name":"Contact","OntologyId":null},"HirnUserId":"daniel_traum@hirnetwork.org","FirstName":"Daniel","LastName":"Traum","EmailAddress":"traum@pennmedicine.upenn.edu","Organization":"University of Pennsylvania","Consortia":[]},{"Role":{"CanonicalId":"hirn-cv-ResourceRole-contact","Url":null,"Name":"Contact","OntologyId":null},"HirnUserId":"golnaz_vahedi@hirnetwork.org","FirstName":"Golnaz","LastName":"Vahedi","EmailAddress":"vahedi@pennmedicine.upenn.edu","Organization":"University of Pennsylvania","Consortia":[]}],"Vendor":{"id":null,"Name":"","Url":""},"VendorResourceName":"","VendorResourceUrl":"","VendorCatNumber":"","VendorLotNumber":"","DateCreated":"2022-03-09T19:57:35.5540955+00:00","DateModified":"2022-07-01T03:37:21.378144+00:00","VersionId":"2","ModelVersion":"4.0","DatasetData":{"DatasetType":{"CanonicalId":"http://purl.bioontology.org/ontology/NCIT?conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C153189","Url":"http://purl.bioontology.org/ontology/NCIT?conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C153189","Name":"Transcriptomics Dataset","OntologyId":"NCIT"},"ExperimentDesign":{"CanonicalId":"","Url":"","Name":"","OntologyId":""},"BiosampleCharacteristics":[{"CanonicalId":"http://purl.obolibrary.org/obo/NCBITaxon_9606","Url":"http://purl.obolibrary.org/obo/NCBITaxon_9606","Name":"Homo sapiens","OntologyId":"ERO"}],"BiosampleType":[{"CanonicalId":"http://purl.obolibrary.org/obo/CLO_0000031","Url":"http://purl.obolibrary.org/obo/CLO_0000031","Name":"cell line","OntologyId":"ERO"}],"TechnologyType":{"CanonicalId":"","Url":"","Name":"","OntologyId":""}}}