{"Id":"2e960ba9-fc5d-4eff-b7ab-c48a7a92b091","CanonicalId":"doi:10.17504/protocols.io.bwddpa26","Url":"https://dx.doi.org/10.17504/protocols.io.bwddpa26","Name":"Single-cell ATAC sequencing","Description":"Interrogating cell-type specific chromatin accessibility can reveal cis-regulatory elements linked to downstream gene expression patterns. Assay for Transposase-Accessible Chromatin using Sequencing (ATAC-Seq) is a technique that assays genome-wide chromatin accessibility and can reveal nucleosome positioning patterns, map enhancer and promoter regions, or reveal transcription factor binding sites. Single-cell Assay for Transposase-Accessible Chromatin using Sequencing (scATAC-seq) adapts the bulk ATAC-sequencing protocol to separate individual nuclei and assay chromatin state with single-cell resolution. This technique allows for resolution of gene accessibility patterns within specific pancreatic cell types such as α-cells, β-cells, and acinar cells.","ResourceType":"Protocol","ParentResourceType":null,"DefiningManuscriptId":"32049053","Publications":[],"Contributors":[{"Role":{"CanonicalId":"hirn-cv-ResourceRole-producer","Url":"resources.hirnetwork.org/api/v1/CV/","Name":"Producer","OntologyId":"HIRN"},"HirnUserId":"klaus_kaestner@hirnetwork.org","FirstName":"Klaus","LastName":"Kaestner","EmailAddress":"kaestner@mail.med.upenn.edu","Organization":"University of Pennsylvania","Consortia":["CTAR","HPAC","OPP","CBDS"]}],"Vendor":{"id":null,"Name":null,"Url":null},"VendorResourceName":null,"VendorResourceUrl":null,"VendorCatNumber":null,"VendorLotNumber":null,"DateCreated":"2021-08-24T16:36:57.8788043+00:00","DateModified":"2022-07-01T03:36:55.5921676+00:00","VersionId":"1","ModelVersion":"4.0","ProtocolData":{"ProtocolType":{"CanonicalId":null,"Url":null,"Name":null,"OntologyId":null},"DocumentId":null,"ProtocolSpecies":[],"DocumentTopic":[]}}