{"Id":"85956cd0-37ee-4dcb-a7d6-7387ac148f93","CanonicalId":"GSE174679","Url":"https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE174679","Name":"Next-generation-sequencing (NGS) of ribosome footprintings and poly(A) enriched RNA-seq of mouse insulinoma cell line (MIN6) under acute and chronic endoplasmic reticular stresses","Description":"This data was used to examine how adaptation to chronic ER stress enforces pancreatic beta-cell plasticity.  A total of 18 samples are available. Design: Mouse insulinoma cells MIN6 treated with 200uM of Cyclopiazonic acid for 1 hour (CPA1) and 18 hours (CPA18); an 18-hour DMSO treatment served as the control (CPA0). Ribo-seq and poly(A) enriched RNA-seq (mRNA-seq) were performed on all. There are three independent biological replications each.","ResourceType":"Dataset","ParentResourceType":null,"DefiningManuscriptId":"","Publications":[{"Name":"Adaptation to chronic ER stress enforces pancreatic β-cell plasticity","Url":"https://doi.org/10.1101/2021.05.24.445193","IsHirnPublication":false}],"Contributors":[{"Role":{"CanonicalId":"hirn-cv-ResourceRole-producer","Url":null,"Name":"Producer","OntologyId":null},"HirnUserId":"","FirstName":"Maria","LastName":"Hatzoglou","EmailAddress":"","Organization":null,"Consortia":[]},{"Role":{"CanonicalId":"hirn-cv-ResourceRole-producer","Url":null,"Name":"Producer","OntologyId":null},"HirnUserId":"cxc1036@case.edu","FirstName":"Chien-Wen","LastName":"Chen","EmailAddress":"cxc1036@case.edu","Organization":null,"Consortia":[]},{"Role":{"CanonicalId":"hirn-cv-ResourceRole-contact","Url":null,"Name":"Contact","OntologyId":null},"HirnUserId":"klaus_kaestner@hirnetwork.org","FirstName":"Klaus","LastName":"Kaestner","EmailAddress":"kaestner@mail.med.upenn.edu","Organization":"University of Pennsylvania","Consortia":["CTAR","HPAC","OPP","CBDS"]},{"Role":{"CanonicalId":"hirn-cv-ResourceRole-contact","Url":null,"Name":"Contact","OntologyId":null},"HirnUserId":"clayton_mathews@hirnetwork.org","FirstName":"Clayton","LastName":"Mathews","EmailAddress":"cxm@ufl.edu","Organization":"University of Florida","Consortia":["CMAI","CBDS","OPP","CHIB"]}],"Vendor":{"id":null,"Name":"","Url":""},"VendorResourceName":"","VendorResourceUrl":"","VendorCatNumber":"","VendorLotNumber":"","DateCreated":"2021-08-30T21:22:37.5431865+00:00","DateModified":"2022-07-01T03:37:21.3710665+00:00","VersionId":"3","ModelVersion":"4.0","DatasetData":{"DatasetType":{"CanonicalId":"http://purl.bioontology.org/ontology/NCIT?conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C153189","Url":"http://purl.bioontology.org/ontology/NCIT?conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C153189","Name":"Transcriptomics Dataset","OntologyId":"NCIT"},"ExperimentDesign":{"CanonicalId":"","Url":"","Name":"","OntologyId":""},"BiosampleCharacteristics":[{"CanonicalId":"http://purl.obolibrary.org/obo/NCBITaxon_10090","Url":"http://purl.obolibrary.org/obo/NCBITaxon_10090","Name":"Mus musculus","OntologyId":"ERO"}],"BiosampleType":[{"CanonicalId":"http://purl.obolibrary.org/obo/CLO_0000031","Url":"http://purl.obolibrary.org/obo/CLO_0000031","Name":"cell line","OntologyId":"ERO"}],"TechnologyType":{"CanonicalId":"http://purl.obolibrary.org/obo/OBI_0001271","Url":"http://purl.obolibrary.org/obo/OBI_0001271","Name":"RNA-seq assay","OntologyId":"OBI"}}}