{"Id":"98da3c26-9c61-40ee-a704-dab15bef3162","CanonicalId":"","Url":"","Name":"A microfluidic platform integrating pressure-driven and electroosmotic-driven flow with inline filters for affinity separations","Description":"A microfluidic system that incorporates an online non-competitive assay for glucagon with a 6 pM limit of detection, low enough to measure from a single islet. It was developed to maintain appropriate flow rates in the presence of the high concentration of salt required for the assay through the use of in-line flow sensors. Incorporation of in-line filters allow operation the device for more than 4 hours without clogs. Use of this system enabled highly reproducible injections. Other engineered features improve the utility of device for long-term monitoring of the glucagon release from islets, but has the potential to be applied to a number of other microfluidic separation-based assays as well.","ResourceType":"DeviceEquipmentTechnology","ParentResourceType":"Technology","DefiningManuscriptId":"PMID31983930","Publications":[],"Contributors":[{"Role":{"CanonicalId":"hirn-cv-ResourceRole-producer","Url":"resources.hirnetwork.org/api/v1/CV/","Name":"Producer","OntologyId":"HIRN"},"HirnUserId":"michael_roper@hirnetwork.org","FirstName":"Michael","LastName":"Roper","EmailAddress":"roper@chem.fsu.edu","Organization":"Florida State University","Consortia":["CHIB"]}],"Vendor":{"id":null,"Name":null,"Url":null},"VendorResourceName":null,"VendorResourceUrl":null,"VendorCatNumber":null,"VendorLotNumber":null,"DateCreated":"2021-04-30T01:28:30.3015334+00:00","DateModified":"2022-07-01T03:35:24.6229542+00:00","VersionId":"1","ModelVersion":"4.0","TechnologyData":{"Dependencies":[],"AssayTechnologyData":{"BioSampleType":[],"CellsTestedWith":[],"AssayTarget":{"CanonicalId":null,"Url":null,"Name":null,"OntologyId":null},"AssayCategory":{"CanonicalId":null,"Url":null,"Name":null,"OntologyId":null},"TechnologyType":{"CanonicalId":null,"Url":null,"Name":null,"OntologyId":null},"TechnologyPlatform":null,"CompatibleTools":[]},"DeviceEquipmentTechnologyData":{"CompatibleTools":[],"CellsTestedWith":[],"Placeholder":"Test"},"ServiceTechnologyData":{"CellsTestedWith":[],"Placeholder":"test"},"CodePipelineTechnologyData":{"Placeholder":"Test"}}}