{"Id":"c61faaa8-cf18-11e7-b8c5-c5f835ee25ab","CanonicalId":"MGI:4367910","Url":"http://www.informatics.jax.org/allele/MGI:4367910","Name":"Ffar2-KO","Description":"The Ffar knock-out mouse was used to test the effects of FFAR2 on insulin secretion. Phenotyping shows no differences for glucose homeostasis on normal or high-fat diet (HFD); marginally significant defect in insulin secretion during hyperglycemic clamps; diminished GSIS from islets under high-glucose conditions; on HFD, gains less weight than WT controls, has improved glucose control and lower HOMA index, and has higher energy expenditure accompanied by higher core body temperature.","ResourceType":"ModelOrganism","ParentResourceType":null,"DefiningManuscriptId":"PMID26075576","Publications":[],"Contributors":[{"Role":{"CanonicalId":"hirn-cv-ResourceRole-contact","Url":"resources.hirnetwork.org/api/v1/CV/","Name":"Contact","OntologyId":"HIRN"},"HirnUserId":"raghavendra_mirmira@hirnetwork.org","FirstName":"Raghavendra","LastName":"Mirmira","EmailAddress":"rmirmira@iupui.edu","Organization":"Indiana University","Consortia":["CBDS"]}],"Vendor":{"id":null,"Name":"Deltagen","Url":"http://deltagen2.hospedagemdesites.ws/"},"VendorResourceName":"","VendorResourceUrl":"","VendorCatNumber":"","VendorLotNumber":"","DateCreated":"2017-11-22T00:04:56+00:00","DateModified":"2022-07-01T03:35:50.6442385+00:00","VersionId":"3","ModelVersion":"4.0","ModelOrganismData":{"Species":[{"CanonicalId":"http://purl.bioontology.org/ontology/NCBITAXON/10090","Url":"http://purl.bioontology.org/ontology/NCBITAXON/10090","Name":"Mus musculus","OntologyId":"NCBITAXON"}],"Sex":null,"PrimaryDisease":{"CanonicalId":"","Url":"","Name":"","OntologyId":""},"SecondaryDisease":{"CanonicalId":"","Url":"","Name":"","OntologyId":""},"StrainCategory":[{"CanonicalId":"http://www.ebi.ac.uk/efo/EFO_0004019","Url":"http://www.ebi.ac.uk/efo/EFO_0004019","Name":"Targeted Mutation","OntologyId":"EFO"}],"StrainGeneticBackground":"C57BL/6J","GeneticModifications":"55 bp of exon 3 were replaced with a neo and lacZ cassette","AuthenticationMethod":"Genotype by PCR","AuthenticationFrequency":"","AuthenticationResult":""}}