{"Id":"c6220c08-cf18-11e7-b8c5-c5f835ee25ab","CanonicalId":"","Url":"","Name":"gcgrb-/-","Description":"A zebrafish model in which glucagon receptor (gcgr) signaling has been interrupted; the two gcgr genes (gcgra and gcgrb) which are co-orthologs of human GCGR were inactivated using TALEN-mediated mutagenesis individually and then together. The robust alpha-cell hyperplasia in gcgra-/-;gcgrb-/- larvae can provide a platform to screen for chemical and genetic suppressors, and ultimately to identify the stimulus of alpha-cell hyperplasia and its signaling mechanism.","ResourceType":"ModelOrganism","ParentResourceType":null,"DefiningManuscriptId":"PMID26446275","Publications":[],"Contributors":[{"Role":{"CanonicalId":"hirn-cv-ResourceRole-producer","Url":"resources.hirnetwork.org/api/v1/CV/","Name":"Producer","OntologyId":"HIRN"},"HirnUserId":"al_powers@hirnetwork.org","FirstName":"Al","LastName":"Powers","EmailAddress":"al.powers@vanderbilt.edu","Organization":"Vanderbilt  University","Consortia":["CTAR","CBDS","HPAP","OPP"]}],"Vendor":{"id":null,"Name":"","Url":null},"VendorResourceName":null,"VendorResourceUrl":null,"VendorCatNumber":null,"VendorLotNumber":null,"DateCreated":"2017-11-22T00:04:56+00:00","DateModified":"2022-07-01T03:35:50.6775073+00:00","VersionId":"1","ModelVersion":"4.0","ModelOrganismData":{"Species":[{"CanonicalId":"http://purl.bioontology.org/ontology/NCBITAXON/7955","Url":"http://purl.bioontology.org/ontology/NCBITAXON/7955","Name":"zebrafish","OntologyId":"NCBITAXON"}],"Sex":{"CanonicalId":null,"Url":null,"Name":null,"OntologyId":null},"PrimaryDisease":{"CanonicalId":null,"Url":null,"Name":null,"OntologyId":null},"SecondaryDisease":{"CanonicalId":null,"Url":null,"Name":null,"OntologyId":null},"StrainCategory":[{"CanonicalId":"http://www.ebi.ac.uk/efo/EFO_0004019","Url":"http://www.ebi.ac.uk/efo/EFO_0004019","Name":"Targeted Mutation","OntologyId":"EFO"}],"StrainGeneticBackground":"","GeneticModifications":"1 bp deletion in gcgrb allele","AuthenticationMethod":"Genotype by PCR","AuthenticationFrequency":null,"AuthenticationResult":null}}