{"Id":"c6483180-cf18-11e7-b8c5-c5f835ee25ab","CanonicalId":"RRID:IMSR_JAX:001976","Url":"https://www.jax.org/strain/001976","Name":"NOD","Description":"From Jackson Labs: The NOD/ShiLtJ strain (commonly called NOD) is a polygenic model for autoimmune type 1 diabetes. Diabetes in NOD mice is characterized by hyperglycemia and insulitis, a leukocytic infiltration of the pancreatic islets. Marked decreases in pancreatic insulin content occur in females at about 12 weeks of age and several weeks later in males.  A 2017 phenotyping study found that 90% of females and 52% of males became diabetic by 30 weeks; median female incidence was 18 weeks. Immune phenotypes in the NOD background consist of defects in antigen presentation, T lymphocyte repertoire, NK cell function, macrophage cytokine production, wound healing, and C5 complement. These defects make the NOD background a common choice for immunodeficient mouse strains. Diabetes onset data is available.","ResourceType":"ModelOrganism","ParentResourceType":null,"DefiningManuscriptId":"PMID26910463","Publications":[],"Contributors":[{"Role":{"CanonicalId":"hirn-cv-ResourceRole-contact","Url":"resources.hirnetwork.org/api/v1/CV/","Name":"Contact","OntologyId":"HIRN"},"HirnUserId":"kevan_herold@hirnetwork.org","FirstName":"Kevan","LastName":"Herold","EmailAddress":"Kevan.herold@yale.edu","Organization":"Yale University","Consortia":["CBDS"]}],"Vendor":{"id":"4b4efe23-8931-42fe-a5ae-bd09f0217694","Name":"The Jackson Laboratory","Url":"https://www.jax.org/"},"VendorResourceName":"","VendorResourceUrl":"","VendorCatNumber":"001976","VendorLotNumber":"","DateCreated":"2017-11-22T00:04:57+00:00","DateModified":"2022-07-01T03:35:50.6710033+00:00","VersionId":"18","ModelVersion":"4.0","ModelOrganismData":{"Species":[{"CanonicalId":"http://purl.bioontology.org/ontology/NCBITAXON/10090","Url":"http://purl.bioontology.org/ontology/NCBITAXON/10090","Name":"Mus musculus","OntologyId":"NCBITAXON"}],"Sex":null,"PrimaryDisease":{"CanonicalId":"","Url":"","Name":"","OntologyId":""},"SecondaryDisease":{"CanonicalId":"","Url":"","Name":"","OntologyId":""},"StrainCategory":[{"CanonicalId":"http://www.ebi.ac.uk/efo/EFO_0004005","Url":"http://www.ebi.ac.uk/efo/EFO_0004005","Name":"inbreed","OntologyId":"EFO"}],"StrainGeneticBackground":"","GeneticModifications":"","AuthenticationMethod":"Genotype by PCR","AuthenticationFrequency":"","AuthenticationResult":""}}