{"Id":"c695477c-cf18-11e7-b8c5-c5f835ee25ab","CanonicalId":"","Url":"","Name":"C9orf72-/-","Description":"Mice harboring loss-of-function mutations in the ortholog of C9ORF72 develop splenomegaly, neutrophilia, thrombocytopenia, increased expression of inflammatory cytokines, and severe autoimmunity.","ResourceType":"ModelOrganism","ParentResourceType":null,"DefiningManuscriptId":"PMID27412785","Publications":[],"Contributors":[{"Role":{"CanonicalId":"hirn-cv-ResourceRole-producer","Url":"resources.hirnetwork.org/api/v1/CV/","Name":"Producer","OntologyId":"HIRN"},"HirnUserId":"derrick_rossi@hirnetwork.org","FirstName":"Derrick","LastName":"Rossi","EmailAddress":"derrick.rossi@childrens.harvard.edu","Organization":"Children’s Hospital Corp","Consortia":["CMAI"]}],"Vendor":{"id":null,"Name":"","Url":""},"VendorResourceName":"","VendorResourceUrl":"","VendorCatNumber":"","VendorLotNumber":"","DateCreated":"2017-11-22T00:04:57+00:00","DateModified":"2022-07-01T03:35:50.6695587+00:00","VersionId":"4","ModelVersion":"4.0","ModelOrganismData":{"Species":[{"CanonicalId":"http://purl.bioontology.org/ontology/NCBITAXON/10090","Url":"http://purl.bioontology.org/ontology/NCBITAXON/10090","Name":"Mus musculus","OntologyId":"NCBITAXON"}],"Sex":null,"PrimaryDisease":{"CanonicalId":"","Url":"","Name":"","OntologyId":""},"SecondaryDisease":{"CanonicalId":"","Url":"","Name":"","OntologyId":""},"StrainCategory":[{"CanonicalId":"http://www.ebi.ac.uk/efo/EFO_0004019","Url":"http://www.ebi.ac.uk/efo/EFO_0004019","Name":"Targeted Mutation","OntologyId":"EFO"}],"StrainGeneticBackground":"C57BL/6","GeneticModifications":"LacZ insertion replacing exons 2-6 of the gene C9orf72-/-","AuthenticationMethod":"Genotype by PCR","AuthenticationFrequency":"","AuthenticationResult":""}}