{"Id":"c69a0a32-cf18-11e7-b8c5-c5f835ee25ab","CanonicalId":"RRID:IMSR_JAX:007799","Url":"https://www.jax.org/strain/007799","Name":"NRG","Description":"From Jackson Labs: These mice are most commonly called NRG and are extremely immunodeficient. The mice carry two mutations on the NOD/ShiLtJ genetic background; a targeted knockout mutation in recombination activating gene 1 (Rag1) and a complete null allele of the IL2 receptor common gamma chain (IL2rgnull). The Rag1null mutation renders the mice B and T cell deficient and the IL2rgnull mutation prevents cytokine signaling through multiple receptors, leading to a deficiency in functional NK cells. The severe immunodeficiency allows the mice to be humanized by engraftment of human CD34+ hematopoietic stem cells (HSC) and patient derived xenografts (PDX) at high efficiency. The immunodeficient NRG mice are more resistant to irradiation and genotoxic drugs than mice with a scid mutation in the DNA repair enzyme Prkdc.","ResourceType":"ModelOrganism","ParentResourceType":null,"DefiningManuscriptId":"PMID27496730","Publications":[],"Contributors":[{"Role":{"CanonicalId":"hirn-cv-ResourceRole-contact","Url":"resources.hirnetwork.org/api/v1/CV/","Name":"Contact","OntologyId":"HIRN"},"HirnUserId":"leonard_shultz@hirnetwork.org","FirstName":"Leonard","LastName":"Shultz","EmailAddress":"lenny.shultz@jax.org","Organization":"The Jackson Laboratory","Consortia":["CMAI"]},{"Role":{"CanonicalId":"hirn-cv-ResourceRole-contact","Url":"resources.hirnetwork.org/api/v1/CV/","Name":"Contact","OntologyId":"HIRN"},"HirnUserId":"dale_greiner@hirnetwork.org","FirstName":"Dale","LastName":"Greiner","EmailAddress":"Dale.greiner@umassmed.edu","Organization":"University of Massachusetts Medical School","Consortia":["CMAI"]}],"Vendor":{"id":null,"Name":"","Url":""},"VendorResourceName":"","VendorResourceUrl":"","VendorCatNumber":"","VendorLotNumber":"","DateCreated":"2017-11-22T00:04:57+00:00","DateModified":"2022-07-01T03:35:50.6666622+00:00","VersionId":"5","ModelVersion":"4.0","ModelOrganismData":{"Species":[{"CanonicalId":"http://purl.bioontology.org/ontology/NCBITAXON/10090","Url":"http://purl.bioontology.org/ontology/NCBITAXON/10090","Name":"Mus musculus","OntologyId":"NCBITAXON"}],"Sex":null,"PrimaryDisease":{"CanonicalId":"","Url":"","Name":"","OntologyId":""},"SecondaryDisease":{"CanonicalId":"","Url":"","Name":"","OntologyId":""},"StrainCategory":[{"CanonicalId":"http://www.ebi.ac.uk/efo/EFO_0004003","Url":"http://www.ebi.ac.uk/efo/EFO_0004003","Name":"Congenic Strain","OntologyId":"EFO"},{"CanonicalId":"http://www.ebi.ac.uk/efo/EFO_0004019","Url":"http://www.ebi.ac.uk/efo/EFO_0004019","Name":"Targeted Mutation","OntologyId":"EFO"}],"StrainGeneticBackground":"","GeneticModifications":"","AuthenticationMethod":"Genotype by PCR","AuthenticationFrequency":"","AuthenticationResult":""}}