{"Id":"c6a5aac2-cf18-11e7-b8c5-c5f835ee25ab","CanonicalId":"","Url":"","Name":"Gcg-CreERT2;Rosa26-LSL-YFP","Description":"An improved mouse model for conditional and inducible genetic manipulation in preproglucagon-expressing cell lineages including pancreatic alpha-cells and enteroendocrine L-cells; a useful tool for performing temporally controlled genetic manipulation specifically in these cell types. Injection with tamoxifen induces CreERT2-mediated recombination at the Rosa-LSL-YFP locus with efficiencies of 88% and 95% for perinatal and adult alpha-cells, respectively. Previous models have only 50-70% recombination efficiency in alpha-cells.","ResourceType":"ModelOrganism","ParentResourceType":null,"DefiningManuscriptId":"PMID28271030","Publications":[],"Contributors":[{"Role":{"CanonicalId":"hirn-cv-ResourceRole-producer","Url":"resources.hirnetwork.org/api/v1/CV/","Name":"Producer","OntologyId":"HIRN"},"HirnUserId":"a_ackermann@hirnetwork.org","FirstName":"Amanda","LastName":"Ackermann","EmailAddress":"ackermanna@email.chop.edu","Organization":"University of Pennsylvania","Consortia":["CTAR"]},{"Role":{"CanonicalId":"hirn-cv-ResourceRole-producer","Url":"resources.hirnetwork.org/api/v1/CV/","Name":"Producer","OntologyId":"HIRN"},"HirnUserId":"klaus_kaestner@hirnetwork.org","FirstName":"Klaus","LastName":"Kaestner","EmailAddress":"kaestner@mail.med.upenn.edu","Organization":"University of Pennsylvania","Consortia":["CTAR","HPAP","OPP","CBDS"]}],"Vendor":{"id":null,"Name":"","Url":""},"VendorResourceName":"","VendorResourceUrl":"","VendorCatNumber":"","VendorLotNumber":"","DateCreated":"2017-11-22T00:04:57+00:00","DateModified":"2022-07-01T03:35:50.6729779+00:00","VersionId":"3","ModelVersion":"4.0","ModelOrganismData":{"Species":[{"CanonicalId":"http://purl.bioontology.org/ontology/NCBITAXON/10090","Url":"http://purl.bioontology.org/ontology/NCBITAXON/10090","Name":"Mus musculus","OntologyId":"NCBITAXON"}],"Sex":null,"PrimaryDisease":{"CanonicalId":"","Url":"","Name":"","OntologyId":""},"SecondaryDisease":{"CanonicalId":"","Url":"","Name":"","OntologyId":""},"StrainCategory":[{"CanonicalId":"http://www.ebi.ac.uk/efo/EFO_0004020","Url":"http://www.ebi.ac.uk/efo/EFO_0004020","Name":"Transgenic Strain","OntologyId":"EFO"}],"StrainGeneticBackground":"C57BL/6","GeneticModifications":"","AuthenticationMethod":"Genotype by PCR","AuthenticationFrequency":"","AuthenticationResult":""}}