{"Id":"de2b50ce-27e5-4825-b8dc-ff4c6fb93d5f","CanonicalId":"","Url":"","Name":"Tg(hs:CS-βmir-21)","Description":"This zebrafish model, engineered for heat-shock inducible miR-21 overexpression specifically within beta cells, has been used to study how miR-21 overexpression leads to beta cell dedifferentiation. It was generated through swapping out the original H2B-GFP sequence with a pre-miR-21 amplicon in the transgenesis vector used to make the Tg(hs:CS) transgenic line. By intercrossing with Tg(ins:Cre)s924 fish, this further allows induction of miR-21 specifically in beta cells.","ResourceType":"ModelOrganism","ParentResourceType":null,"DefiningManuscriptId":"PMID:34246804","Publications":[],"Contributors":[{"Role":{"CanonicalId":"hirn-cv-ResourceRole-producer","Url":"resources.hirnetwork.org/api/v1/CV/","Name":"Producer","OntologyId":"HIRN"},"HirnUserId":"emily_sims@hirnetwork.org","FirstName":"Emily","LastName":"Sims","EmailAddress":"eksims@iu.edu","Organization":"Indiana University School of Medicine","Consortia":[]}],"Vendor":{"id":null,"Name":"","Url":null},"VendorResourceName":null,"VendorResourceUrl":"","VendorCatNumber":"","VendorLotNumber":"","DateCreated":"2021-08-13T17:23:30.7214473+00:00","DateModified":"2022-07-01T03:35:50.7497462+00:00","VersionId":"1","ModelVersion":"4.0","ModelOrganismData":{"Species":[{"CanonicalId":"http://purl.bioontology.org/ontology/NCBITAXON/7955","Url":"http://purl.bioontology.org/ontology/NCBITAXON/7955","Name":"zebrafish","OntologyId":"NCBITAXON"}],"Sex":{"CanonicalId":null,"Url":null,"Name":null,"OntologyId":null},"PrimaryDisease":{"CanonicalId":null,"Url":null,"Name":null,"OntologyId":null},"SecondaryDisease":{"CanonicalId":null,"Url":null,"Name":null,"OntologyId":null},"StrainCategory":[{"CanonicalId":"http://www.ebi.ac.uk/efo/EFO_0004020","Url":"http://www.ebi.ac.uk/efo/EFO_0004020","Name":"Transgenic Strain","OntologyId":"EFO"}],"StrainGeneticBackground":"","GeneticModifications":"","AuthenticationMethod":"","AuthenticationFrequency":"","AuthenticationResult":""}}