{"Id":"e9a24fb0-d3c0-11e7-8297-97826e1cd59d","CanonicalId":"RRID:SCR_015809","Url":"https://europepmc.org/abstract/med/28851858","Name":"DexMA hydrogel model of extracellular matrix","Description":"This new class of synthetic hydrogel can more precisely model a natural matrix structure by resisting swelling upon hydration, as well as being tunable for stiffness using MMP-degradable crosslinks. The gel was integrated with a microfluidic device to recapitulate a dynamic landscape for endothelial cell migration. Because of its non-swelling properties, the gel can host soluble chemokine gradients to stimulate cell migration, while the gel's own degradability by cell-produced matrix metalloproteinases (MMPs) makes it a more truly interactive model system. ","ResourceType":"DeviceEquipmentTechnology","ParentResourceType":"Technology","DefiningManuscriptId":"PMID28851858","Publications":[],"Contributors":[{"Role":{"CanonicalId":"hirn-cv-ResourceRole-producer","Url":"resources.hirnetwork.org/api/v1/CV/","Name":"Producer","OntologyId":"HIRN"},"HirnUserId":"chris_chen@hirnetwork.org","FirstName":"Chris","LastName":"Chen","EmailAddress":"chencs@bu.edu","Organization":"Boston University","Consortia":["CHIB"]}],"Vendor":{"id":null,"Name":"","Url":null},"VendorResourceName":null,"VendorResourceUrl":null,"VendorCatNumber":"","VendorLotNumber":"","DateCreated":"2017-11-23T02:20:46.3988526+00:00","DateModified":"2022-07-01T03:35:24.6160947+00:00","VersionId":"1","ModelVersion":"4.0","TechnologyData":{"Dependencies":[{"CanonicalId":"http://purl.obolibrary.org/obo/ERO_0000479","Url":"http://purl.obolibrary.org/obo/ERO_0000479","Name":"chemical synthesis","OntologyId":"ERO"},{"CanonicalId":"http://purl.obolibrary.org/obo/ERO_0001324","Url":"http://purl.obolibrary.org/obo/ERO_0001324","Name":"fabrication","OntologyId":"ERO"}],"AssayTechnologyData":{"BioSampleType":[],"CellsTestedWith":[{"CanonicalId":"http://purl.obolibrary.org/obo/CL_0000057","Url":"http://purl.obolibrary.org/obo/CL_0000057","Name":"fibroblast","OntologyId":"CL"}],"AssayTarget":{"CanonicalId":null,"Url":null,"Name":null,"OntologyId":null},"AssayCategory":{"CanonicalId":null,"Url":null,"Name":null,"OntologyId":null},"TechnologyType":{"CanonicalId":null,"Url":null,"Name":null,"OntologyId":null},"TechnologyPlatform":null,"CompatibleTools":[{"CanonicalId":"http://purl.obolibrary.org/obo/ERO_0001000","Url":"http://purl.obolibrary.org/obo/ERO_0001000","Name":"fluidics platform","OntologyId":"ERO"},{"CanonicalId":"http://purl.obolibrary.org/obo/ERO_0001356","Url":"http://purl.obolibrary.org/obo/ERO_0001356","Name":"fluorescent microscopy","OntologyId":"ERO"}]},"DeviceEquipmentTechnologyData":{"CompatibleTools":[],"CellsTestedWith":[],"Placeholder":"Test"},"ServiceTechnologyData":{"CellsTestedWith":[],"Placeholder":"test"},"CodePipelineTechnologyData":{"Placeholder":"Test"}}}