{"Id":"ea40805e-4b99-4532-bfbc-b263537ef89d","CanonicalId":"GSE141846","Url":"https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE141846","Name":"ChIP-seq data related to Type 1 Diabetes Reconfigure the 3D Chromatin Organization of T Cells","Description":"The data examines reconfiguration of the 3D genome due to nucleotide differences associated with T1D. Chromatin organization at T cell identity genes is identical between diabetes-susceptible and diabetes-resistant mouse strains despite thousands of sequence polymorphisms, suggesting that these loci are epigenetically resilient to genetic variation. However, molecular and optical mapping of genome folding demonstrate that diabetes risk-conferring loci coalesce into close spatial proximity in T cells of diabetes-susceptible mice, forming regulatory cliques, and resulting in aberrant gene expression. Our data uncover 3D chromatin architecture asa new dimension in understanding complex diseases.\n  \t","ResourceType":"Dataset","ParentResourceType":null,"DefiningManuscriptId":"32049053","Publications":[],"Contributors":[{"Role":{"CanonicalId":"hirn-cv-ResourceRole-producer","Url":"resources.hirnetwork.org/api/v1/CV/","Name":"Producer","OntologyId":"HIRN"},"HirnUserId":"klaus_kaestner@hirnetwork.org","FirstName":"Klaus","LastName":"Kaestner","EmailAddress":"kaestner@mail.med.upenn.edu","Organization":"University of Pennsylvania","Consortia":["CTAR","HPAC","OPP","CBDS"]},{"Role":{"CanonicalId":"hirn-cv-ResourceRole-producer","Url":"resources.hirnetwork.org/api/v1/CV/","Name":"Producer","OntologyId":"HIRN"},"HirnUserId":"ali_naji@hirnetwork.org","FirstName":"Ali","LastName":"Naji","EmailAddress":"Ali.Naji@uphs.upenn.edu","Organization":"University of Pennsylvania","Consortia":["HPAC","CBDS","CHIB"]}],"Vendor":{"id":null,"Name":"","Url":""},"VendorResourceName":"","VendorResourceUrl":"","VendorCatNumber":"","VendorLotNumber":"","DateCreated":"2021-05-04T00:15:07.0281117+00:00","DateModified":"2022-07-01T03:35:35.9395658+00:00","VersionId":"1","ModelVersion":"4.0","DatasetData":{"DatasetType":{"CanonicalId":"http://purl.bioontology.org/ontology/NCIT?conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C153190","Url":"http://purl.bioontology.org/ontology/NCIT?conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C153190","Name":"Epigenomics Dataset","OntologyId":"NCIT"},"ExperimentDesign":{"CanonicalId":"","Url":"","Name":"","OntologyId":""},"BiosampleCharacteristics":[{"CanonicalId":"http://purl.obolibrary.org/obo/NCBITaxon_10090","Url":"http://purl.obolibrary.org/obo/NCBITaxon_10090","Name":"Mus musculus","OntologyId":"ERO"}],"BiosampleType":[{"CanonicalId":"http://purl.obolibrary.org/obo/CL_0000084","Url":"http://purl.obolibrary.org/obo/CL_0000084","Name":"T cell","OntologyId":"CL"}],"TechnologyType":{"CanonicalId":"http://purl.obolibrary.org/obo/OBI_0000716","Url":"http://purl.obolibrary.org/obo/OBI_0000716","Name":"ChIP-seq assay","OntologyId":"OBI"}}}