{"Id":"f31e6c19-20e9-4d6a-8168-7806981d9ead","CanonicalId":"","Url":"","Name":"In vivo-mimicking microfluidic platform for perfusion culture of pancreatic islet spheroids","Description":"A microfluidic chip to establish functional islet spheroids through mimicking interstitial flow conditions with reduced shear cell damage. Optimized flow condition allowed localization of secreted soluble factors near spheroids, facilitating diffusion-mediated paracrine interactions within islets, and enabled long-term maintenance of islet morphology and function for a month. The proposed model can aid islet preconditioning before transplantation and has potential applications as an in vitro model for diabetic drug testing. ","ResourceType":"DeviceEquipmentTechnology","ParentResourceType":"Technology","DefiningManuscriptId":"PMID31807701","Publications":[],"Contributors":[{"Role":{"CanonicalId":"hirn-cv-ResourceRole-producer","Url":"resources.hirnetwork.org/api/v1/CV/","Name":"Producer","OntologyId":"HIRN"},"HirnUserId":"maike_sander@hirnetwork.org","FirstName":"Maike","LastName":"Sander","EmailAddress":"masander@ucsd.edu","Organization":"University of California, San Diego","Consortia":["CHIB","HPAC"]}],"Vendor":{"id":null,"Name":null,"Url":null},"VendorResourceName":null,"VendorResourceUrl":null,"VendorCatNumber":null,"VendorLotNumber":null,"DateCreated":"2021-04-30T01:28:30.3015334+00:00","DateModified":"2022-07-01T03:35:24.6222445+00:00","VersionId":"1","ModelVersion":"4.0","TechnologyData":{"Dependencies":[],"AssayTechnologyData":{"BioSampleType":[],"CellsTestedWith":[],"AssayTarget":{"CanonicalId":null,"Url":null,"Name":null,"OntologyId":null},"AssayCategory":{"CanonicalId":null,"Url":null,"Name":null,"OntologyId":null},"TechnologyType":{"CanonicalId":null,"Url":null,"Name":null,"OntologyId":null},"TechnologyPlatform":null,"CompatibleTools":[]},"DeviceEquipmentTechnologyData":{"CompatibleTools":[],"CellsTestedWith":[],"Placeholder":"Test"},"ServiceTechnologyData":{"CellsTestedWith":[],"Placeholder":"test"},"CodePipelineTechnologyData":{"Placeholder":"Test"}}}