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Technology / AssayTechnology
Resource Name

Assay using circulating unmethylated CHTOP and INS DNA fragments for assessment of islet cell death

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Description
CHTOP was identified as a gene whose CpGs show a greater frequency of unmethylation in human islets. A digital PCR strategy was used to determine the methylation pattern of CHTOP and INS CpG sites in primary human tissues. Although both INS and CHTOP contained unmethylated CpG sites in non-islet tissues, they occurred in a non-overlapping pattern. Based on Naïve Bayes classifier analysis, the two genes together report 100% specificity for islet damage.
Contributors
NameOrganizationConsortiumContact
Bobbie-Jo Webb-RobertsonPacific Northwest National LaboratoryCBDS Contact
Bobbie-Jo Webb-RobertsonPacific Northwest National LaboratoryCBDS Contact
Carmella Evans-MolinaIndiana University Contact
Decio EizirikUniversity of BrusselsCBDS Contact
Raghavendra MirmiraIndiana UniversityCBDS Contact
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