Resource Type
Technology / AssayTechnology
Resource Name

Assay using serum Proinsulin:C-peptide (PI:C) ratio and HSP90 as indicators of beta-cell stress
Canonical Identifier
Description
The utility of this assay has been tested with NOD mice and a cohort of new-onset T1D subjects in a pilot study. Both HSP90 levels and the PI:C ratio were significantly higher in new-onset subjects compared with healthy, nondiabetic controls. The assay could be a useful complement to other characterizations of beta cell stress.
Contributors
NameOrganizationConsortiumContact
Carmella Evans-MolinaIndiana University Contact
Raghavendra MirmiraIndiana UniversityCBDS Contact
Tags or Keywords
Defining Manuscript Identifier
PMID26397425


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