Resource Type
Technology / AssayTechnology
Resource Name

IRE1alpha high-throughput interactome screen based on ArrayMAPPIT and Binary MAPPIT (mammalian protein-protein interaction trap)
Canonical Identifier
Description
A useful example of adapting the previously described ArrayMAPPIT system to investigate the unfolded protein response (UPR) in beta cell apoptosis. Protein-protein interactions are identified with IRE1alpha, a key player in the transition to �apoptotic� UPR, constructed as bait in ArrayMAPPIT. The same IRE1alpha bait is used in BinaryMAPPIT to confirm interactions, i.e. with UBD.
Tags or Keywords
Defining Manuscript Identifier
PMID27044747
Related Resources
Canonical IdentifierNameResource Type
NODModelOrganism
NOD-scidModelOrganism


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