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RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes

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Pancreatic islet cells are critical for maintaining normal blood glucose levels and their malfunction underlies diabetes development and progression. We used single-cell RNA sequencing to determine the transcriptomes of 1,492 human pancreatic α-, β-, δ- and PP cells from non-diabetic and type 2 diabetes organ donors. We identified cell type specific genes and pathways as well as 245 genes with disturbed expression in type 2 diabetes. Importantly, 92% of the genes have not previously been associated with islet cell function or growth. Comparison of gene profiles in mouse and human α- and β-cells revealed species-specific expression. All data are available for online browsing and download and will hopefully serve as a resource for the islet research community.
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RNA-Seq

Publications
PMID36197983 HIRN SUPPORTED

Contacts
Rafael Drigo
Patrick MacDonald
RNA-Seq

Publications
PMID34052132 HIRN SUPPORTED

Contacts
Patrick MacDonald
RNA-Seq

Publications
PMID36928765 HIRN SUPPORTED

Contacts
Mark Huising
transcriptomic data

Publications
PMID37435358 HIRN SUPPORTED

Contacts
Lotte Vanheer
single-cell RNA sequencing

Publications
PMID37697055 HIRN SUPPORTED

Contacts
Heiko Lickert


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