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Technology / DeviceEquipmentTechnology |
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Constant-distance Mode Nanospray Desorption Electrospray Ionization Mass Spectrometry (nano-DESI MSI) |
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This approach describes a modification to nano-DESI MSI that uses shear force microscopy to precisely control the distance between the sample and the nano-DESI probe. It allowed robust imaging of pancreatic islets with high spatial resolution of ~11 μm, overcoming limitations of traditional mass spec approaches. It also allowed lipidomics to be studied with spatial distribution information in invidual islets. |
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| Jennifer Kyle | Pacific Northwest National Laboratory | | Contact | | Kristin Burnum-Johnson | Pacific Northwest National Laboratory | CBDS | Contact | | Lori Sussel | University of Colorado, Denver | | Contact | | Charles Ansong | Pacific Northwest National Laboratory | CBDS | Contact | | Julia Laskin | Purdue University | CBDS | Contact |
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