Resource Type
Technology / DeviceEquipmentTechnology
Resource Name

Constant-distance Mode Nanospray Desorption Electrospray Ionization Mass Spectrometry (nano-DESI MSI)
Canonical Identifier
RRID:SCR_017130
Description
This approach describes a modification to nano-DESI MSI that uses shear force microscopy to precisely control the distance between the sample and the nano-DESI probe. It allowed robust imaging of pancreatic islets with high spatial resolution of ~11 μm, overcoming limitations of traditional mass spec approaches. It also allowed lipidomics to be studied with spatial distribution information in invidual islets.
Contributors
NameOrganizationConsortiumContact
Jennifer KylePacific Northwest National Laboratory Contact
Kristin Burnum-JohnsonPacific Northwest National LaboratoryCBDS Contact
Lori SusselUniversity of Colorado, Denver Contact
Charles AnsongPacific Northwest National LaboratoryCBDS Contact
Julia LaskinPurdue UniversityCBDS Contact
Defining Manuscript Identifier
PMID29718662


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