Resource Type
ModelOrganism
Resource Name

serpinb1-overexpressing
Canonical Identifier
Description
Zebrafish model developed alongside and complementing the serpinB1-KO mouse model. Serpinb1-overexpressing larvae show increased regeneration of the beta-cell mass by 50% after beta-cell ablation, compared to controls.
Contributors
NameOrganizationConsortiumContact
Marina GritsenkoPacific Northwest National Laboratory Contact
Wei-Jun QianPacific Northwest National LaboratoryCBDS, OPP Contact
Rohit KulkarniJoslin Diabetes CenterCBDS, CTAR Contact
Defining Manuscript Identifier
PMID26701651
Related Resources
Canonical IdentifierNameResource Type
liver insulin receptor knockout (LIRKO)ModelOrganism
Proteomics and phosphoproteomics of beta-cell response to SerpinB1 (inducer of beta-cell proliferation)Dataset
serpinb1a-/- (serpinB1-KO)ModelOrganism


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Species
Strain Category
Genetic Modifications
cloning of serpinb1 downstream of beta-actin to generate widespread mosaic overexpression of serpinb1
Authentication Method
Genotype by PCR



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