Resource Type
ModelOrganism
Resource Name

MIP-CreER;CDK4+/R24C
Canonical Identifier
Description
A double transgenic strain with beta cell-specific activation of CDK4^R24C through tamoxifen induction. When induced, islets from these mice showed lower GSIS than control, providing evidence that constitutively active CDK4 mimics the effect of p16 deficiency (given that p16 is the inhibitor of CDK4).
Contributors
NameOrganizationConsortiumContact
Chunhua DaiVanderbilt UniversityCTAR Contact
Benjamin GlaserHadassah-Hebrew UniversityCTAR Contact
Al PowersVanderbilt UniversityCTAR, CBDS, HPAP, OPP Contact
Yuval DorHebrew University of JerusalemCBDS, OPP Contact
Tags or Keywords
Defining Manuscript Identifier
PMID26950362
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Species
Strain Category
Strain Genetic Background
mixed ICR
Authentication Method
Genotype by PCR



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