G6pc2 KO mice on a mixed 129SvEvBRD x C57BL/6J and then backcrossed onto pure 129SvEvBRD. (Acute treatment with dexamethasone selectively induces endogenous G6pc2 expression in 129SvEv but not C57BL/6J mouse pancreas and isolated islets.) In 6-hour fasted, nonstressed 129SvEv mice, deletion of G6pc2 lowers fasting blood glucose (FBG). In response to the stress of repeated physical restraint, which is associated with elevated plasma glucocorticoid levels, G6pc2 gene expression is induced and the difference in FBG between wild-type and knockout mice is enhanced.