Resource Type
ModelOrganism
Resource Name

betaPAX6
Canonical Identifier
Alternative/Secondary Identifiers
CanonicalIdName
MIP-CreER Pax6fl/fl Rosa26-LSL-YFP
Description
Strain used for investigating the role of Pax6 in beta cell development; features conditional deletion of Pax6 in beta cells and YFP reporter for genetic lineage tracing. Injection of tamoxifen into betaPAX6 mice results in rapid and efficient loss of PAX6 protein in more than 90% of beta cells.
Contributors
NameOrganizationConsortiumContact
Klaus KaestnerUniversity of PennsylvaniaCTAR, HPAP, OPP, CBDS Contact
Benjamin GlaserHadassah-Hebrew UniversityCTAR Contact
Yuval DorHebrew University of JerusalemCBDS, OPP Contact
Tags or Keywords
Defining Manuscript Identifier
PMID27941241
Related Resources
Canonical IdentifierNameResource Type
BKS db (db/db)ModelOrganism
RRID:IMSR_JAX:024709MIP-CreERModelOrganism
RRID:IMSR_JAX:28032Pax6fl/flModelOrganism
RRID:IMSR_JAX:006148R26R-EYFPModelOrganism
GSE87530Whole genome map of PAX6 bound sites from Min6 and EndoC cells (n=3); whole genome map of histones enriched for H3K9ac modification from pancreatic beta cells of Bl6 miceDataset


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Species
Strain Category
Strain Genetic Background
C57BL/6
Authentication Method
Genotype by PCR



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