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Search Results for: Al Powers returned 469 results
Rosa26-LSL-Kir6.2-V59M Strain reporting expression of KATP channel subunit Kir6.2; described in (Girard et al., 2009) |
TetO-Cre Triple transgenic strain described in (Perl et al., 2002); combines tet dependent expression of Cre under control of the surfactant protein C (SP-C) promoter. |
Gcgr-/- MGI:3505881 Mice lacking glucagon receptor have been characterized with mild hypoglycemia, alpha-cell hyperplasia and hypertrophy, and altered responses to intraperitoneal glucose and insulin tolerance tests. Pups born from Gcgr-/- mothers die perinatally. |
Ezh2fl/fl Strain containing Cre-recombinase-sensitive floxed Ezh2 allele (an epigenetic regulator of embryonic development); described in (Su et al., 2003). |
INS-1 832/13 RRID:CVCL_7226 INS-1-derived cell line with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion (Hohmeier et al., 2000) |
TetO-Cre Triple transgenic strain described in (Perl et al., 2002); combines tet dependent expression of Cre under control of the surfactant protein C (SP-C) promoter. |
HPa3 / HIC3-2D12 antibody RRID:AB_2631139 |
CDK4+/lsl-R24C Strain carrying the CDK^R24C allele preceded by a lox-stop-lox (lsl) cassette. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. (Rane SG, et al. 1999) |
Gcg-rtTA Transgenic strain in which only alpha-cells can be selectively and irreversibly labeled before beta-cell ablation (tetracycline-dependent Cre/loxP system); carries the TetO-Cre responder transgene, the reporter R26-YFP 26, and the RIP-DTR transgene. TetO drives the expression of Cre recombinase after rtTA activation with the tetracycline analog doxycycline (DOX, |
MIN6 RRID:CVCL_0431 Immortalized beta cell-derived cell line. Comments: MIN6 is not a pure beta cell line but a mixed cell line with other pancreatic endocrine hormones (Nakashima et al., 2009) High passage MIN6 cells have impaired insulin secretion with impaired glucose and lipid oxidation. (Cheng et al., 2012) |
Anti-Caveolin-1 Antibody RRID:AB_303405 |
B6.129S7-Slc7a2tm1Clm/LellJ RRID:IMSR_JAX:022767 |
CYP26A1 (F27 P6 A1) antibody RRID:AB_2089263 |
GATA2 monoclonal antibody (M01), clone 2D11 RRID:AB_489737 |
CD44 antibody RRID:AB_2847859 |
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