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Search Results for: Leonard Shultz returned 167 results
NSG-huL15 RRID:IMSR_JAX:030890 Transgenic expression of human IL15. Supports NK development following human HSC engraftment |
PE anti-human CD66b Antibody RRID:AB_2077857 |
NSG-(KbDb)nullIA RRID:IMSR_JAX:025216 Lack of mouse MHC class I and II |
NOD.Cg-KitW-41J Tyr + Prkdcscid Il2rgtm1Wjl/ThomJ RRID:IMSR_JAX:026622 Supports human HSC engraftment without irradiation |
Brilliant Violet 785™ anti-human CD8a Antibody RRID:AB_2563264 |
NSG-Gcg KO RRID:IMSR_JAX:029819 Preproglucanon null allele. Supports human islet alpha cell engraftment |
NSG RRID:IMSR_JAX:005557 From Brehm et al: No mature T cells, B cells, NK cells; radiosensitive. From Jackson Labs: These mice are most often referred to using their branded name NSG and are extremely immunodeficient. The mice carry two mutations on the NOD/ShiLtJ genetic background; severe combined immune deficiency (scid) and a complete null allele of the IL2 receptor common gamma chain (IL2rgnull). The scid mutation is in the DNA repair complex protein Prkdc and renders the mice B and T cell deficient. The IL2rgnull mutation prevents cytokine signaling through multiple receptors, leading to a deficiency in functional NK cells. The severe immunodeficiency allows the mice to be humanized by engraftment of human CD34+ hematopoietic stem cells (HSC), peripheral blood mononuclear cells (PBMC), patient derived xenografts (PDX), or adult stem cells and tissues. The immunodeficient NSG mice enable research in human immune function, infectious disease, diabetes, oncology, and stem cell biology. |
BD Pharmingen™ Alexa Fluor® 647 Mouse Anti-Human RORγt Antibody RRID:AB_2738324 |
Pacific Blue™ anti-human/mouse Granzyme B Antibody RRID:AB_2562196 |
BD OptiBuild™ BUV805 Mouse Anti-Human CD337 (NKp30) Antibody RRID:AB_2873516 |
Alexa Fluor® 700 anti-mouse CD45 Antibody RRID:AB_493715 |
BD Horizon™ BV750 Mouse Anti-Human TNF Antibody RRID:AB_2739709 |
BD Horizon™ BV786 Mouse Anti-Human CD107a Antibody RRID:AB_2738458 |
Brilliant Violet 510™ anti-human CD69 Antibody RRID:AB_2563834 |
Alexa Fluor® 700 anti-human IFN-γ Antibody RRID:AB_528921 |
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