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Search Results for: Michael Brehm returned 114 results
NSG-SGM3 RRID:IMSR_JAX:013062 Transgenic expression of hu IL3, GM-CSF and KitL. Enhanced myeloid, AML and regulatory T cell engraftment |
NOD.Cg-KitW-41J Tyr + Prkdcscid Il2rgtm1Wjl/ThomJ RRID:IMSR_JAX:026622 Supports human HSC engraftment without irradiation |
The emergent landscape of the mouse gut endoderm at single-cell resolution GSE123046 |
NSG RRID:IMSR_JAX:005557 From Brehm et al: No mature T cells, B cells, NK cells; radiosensitive. From Jackson Labs: These mice are most often referred to using their branded name NSG and are extremely immunodeficient. The mice carry two mutations on the NOD/ShiLtJ genetic background; severe combined immune deficiency (scid) and a complete null allele of the IL2 receptor common gamma chain (IL2rgnull). The scid mutation is in the DNA repair complex protein Prkdc and renders the mice B and T cell deficient. The IL2rgnull mutation prevents cytokine signaling through multiple receptors, leading to a deficiency in functional NK cells. The severe immunodeficiency allows the mice to be humanized by engraftment of human CD34+ hematopoietic stem cells (HSC), peripheral blood mononuclear cells (PBMC), patient derived xenografts (PDX), or adult stem cells and tissues. The immunodeficient NSG mice enable research in human immune function, infectious disease, diabetes, oncology, and stem cell biology. |
NSG-(KbDb)nullIA RRID:IMSR_JAX:025216 Lack of mouse MHC class I and II |
Human HNF-3 beta /FoxA2 Antibody RRID:AB_2294104 |
NSG-huL15 RRID:IMSR_JAX:030890 Transgenic expression of human IL15. Supports NK development following human HSC engraftment |
BD Pharmingen™ Purified NA/LE Mouse Anti-Human HLA-DR, DP, DQ Antibody RRID:AB_395938 |
Single-cell RNA sequencing-based CRISPRi screening resolves molecular drivers of early human endoderm development [set 1] GSE127199 |
Single-cell RNA sequencing-based CRISPRi screening resolves molecular drivers of early human endoderm development [set 2] GSE127201 |
Recombinant Anti-GATA3 Antibody RRID:AB_2819013 |
Pbx1 Antibody RRID:AB_2160295 |
Purified anti-human CD326 (EpCAM) Antibody RRID:AB_756076 |
Single-cell genomics profiling of the endoderm of the mouse embryonic pharynx [scRNA-seq] GSE182135 |
FOXE1 Polyclonal Antibody RRID:AB_10983805 |
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