Resource Type
Technology / DeviceEquipmentTechnology
Resource Name

In vivo-mimicking microfluidic platform for perfusion culture of pancreatic islet spheroids

Canonical Identifier
Description
A microfluidic chip to establish functional islet spheroids through mimicking interstitial flow conditions with reduced shear cell damage. Optimized flow condition allowed localization of secreted soluble factors near spheroids, facilitating diffusion-mediated paracrine interactions within islets, and enabled long-term maintenance of islet morphology and function for a month. The proposed model can aid islet preconditioning before transplantation and has potential applications as an in vitro model for diabetic drug testing.
Contributors
NameOrganizationConsortiumContact
Maike SanderUniversity of California, San DiegoCHIB, HPAC Contact
Defining Manuscript Identifier


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