Resource Type
ModelOrganism
Resource Name

gcgrb-/-
Canonical Identifier
Alternative/Secondary Identifiers
CanonicalIdName
gcgrbvu601
Description
A zebrafish model in which glucagon receptor (gcgr) signaling has been interrupted; the two gcgr genes (gcgra and gcgrb) which are co-orthologs of human GCGR were inactivated using TALEN-mediated mutagenesis individually and then together. The robust alpha-cell hyperplasia in gcgra-/-;gcgrb-/- larvae can provide a platform to screen for chemical and genetic suppressors, and ultimately to identify the stimulus of alpha-cell hyperplasia and its signaling mechanism.
Contributors
NameOrganizationConsortiumContact
Al PowersVanderbilt UniversityCTAR, CBDS, HPAP, OPP Contact
Defining Manuscript Identifier
PMID26446275
Related Resources
Canonical IdentifierNameResource Type
gcgra-/-ModelOrganism
Tg(gcga:EGFP) AB strainModelOrganism


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Species
Strain Category
Genetic Modifications
1 bp deletion in gcgrb allele
Authentication Method
Genotype by PCR



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